4) Batman vs. The Joker (Batman)

3) Harry Potter vs. Lord Voldermort (Harry Potter)

2) Ellen Ripley vs. The Alien (Alien)

1) Darth Vader vs. Luke Skywalker (Star Wars)

When I finally started researching this list, I realized there were hundreds of ways you could go, and dozens of pretty obvious choices. Narrowing it to five was a challenge.

We also received a number of votes for Carl Spackler vs. the Gopher (Caddyshack), Martin Brody vs. the shark (Jaws), Rocky vs. Apollo Creed, Neo vs. Agent Smith (The Matrix), and one clever nomination of Nicolas Cage vs. the bottle (Leaving Las Vegas).